Existing classes of antibiotics are probably the best we will ever haveBMJ 2012; 344 doi: http://dx.doi.org/10.1136/bmj.e3369 (Published 15 May 2012) Cite this as: BMJ 2012;344:e3369
- Martin Cormican, medical microbiologist1,
- Akke Vellinga, epidemiologist1
- 1School of Medicine (General Practice and Bacteriology), National University of Ireland Galway, Galway, Republic of Ireland
Paccaud emphasises economic incentives for new antibiotic discovery to tackle antibiotic resistance.1 An ecological perspective suggests that new drug discovery may not make a major contribution.
The ideal target for antibiotic action is a crucial step in bacterial physiology with no parallel in mammalian cells—for example, penicillin targets a step in cell wall synthesis. Because there …