Prevention of acute knee injuries in adolescent female football players: cluster randomised controlled trialBMJ 2012; 344 doi: http://dx.doi.org/10.1136/bmj.e3042 (Published 03 May 2012) Cite this as: BMJ 2012;344:e3042
- Markus Waldén, senior researcher12,
- Isam Atroshi, associate professor23,
- Henrik Magnusson, statistician4,
- Philippe Wagner, statistician5,
- Martin Hägglund, senior researcher4
- 1Division of Community Medicine, Department of Medical and Health Sciences, Linköping University, 581 83 Linköping, Sweden
- 2Department of Orthopaedics, Hässleholm-Kristianstad-Ystad Hospitals, 281 25 Hässleholm, Sweden
- 3Department of Clinical Sciences, Lund University, 221 84 Lund, Sweden
- 4Division of Physiotherapy, Department of Medical and Health Sciences, Linköping University
- 5National Competence Centre for Musculoskeletal Disorders, Lund University
- Correspondence to: M Waldén
- Accepted 23 March 2012
Objective To evaluate the effectiveness of neuromuscular training in reducing the rate of acute knee injury in adolescent female football players.
Design Stratified cluster randomised controlled trial with clubs as the unit of randomisation.
Setting 230 Swedish football clubs (121 in the intervention group, 109 in the control group) were followed for one season (2009, seven months).
Participants 4564 players aged 12-17 years (2479 in the intervention group, 2085 in the control group) completed the study.
Intervention 15 minute neuromuscular warm-up programme (targeting core stability, balance, and proper knee alignment) to be carried out twice a week throughout the season.
Main outcome measures The primary outcome was rate of anterior cruciate ligament injury; secondary outcomes were rates of severe knee injury (>4 weeks’ absence) and any acute knee injury.
Results Seven players (0.28%) in the intervention group, and 14 (0.67%) in the control group had an anterior cruciate ligament injury. By Cox regression analysis according to intention to treat, a 64% reduction in the rate of anterior cruciate ligament injury was seen in the intervention group (rate ratio 0.36, 95% confidence interval 0.15 to 0.85). The absolute rate difference was −0.07 (95% confidence interval −0.13 to 0.001) per 1000 playing hours in favour of the intervention group. No significant rate reductions were seen for secondary outcomes.
Conclusions A neuromuscular warm-up programme significantly reduced the rate of anterior cruciate ligament injury in adolescent female football players. However, the absolute rate difference did not reach statistical significance, possibly owing to the small number of events.
Trial registration Clinical trials NCT00894595.
Football (soccer) is the most popular sport worldwide with around 265 million players, and the number of female players is growing rapidly.1 For example, more than three million young people play football in the United States alone, and almost half of them are female2; and in 2006 around 83 000 female football players from the age of 12 years were registered in Sweden (population around 9 million).3 Unfortunately, knee injuries are common, and severe injuries such as anterior cruciate ligament injury constitute a serious problem in terms of long absence from or termination of football and early osteoarthritis.4 5 6 7 8
In football, the rate of anterior cruciate ligament injury is more than twofold higher in female players than in male players,9 10 and adolescent girls are especially at risk.10 11 Several parallel group controlled studies, most targeting adolescents, have evaluated injury prevention strategies in female football players.12 13 14 15 16 17 18 19 20 21 Only two non-randomised studies in adolescent footballers showed significant reduction of acute knee injuries or non-contact anterior cruciate ligament injuries with neuromuscular warm-up programmes.16 17 However, most studies were not designed specifically to evaluate preventive effects on knee or anterior cruciate ligament injury as the primary outcome, and high quality randomised controlled trials targeting prevention of acute knee injuries or anterior cruciate ligament injuries are lacking.22
The main objective of our stratified cluster randomised controlled trial was to evaluate the effectiveness of a neuromuscular warm-up programme in reducing the rate of acute knee injury, particularly anterior cruciate ligament injury, in adolescent female football players. Our hypothesis was that the rates of anterior cruciate ligament injury and acute knee injury would be significantly reduced in the intervention group compared with the control group.
Study design and participants
The study was a two armed, parallel group, cluster randomised controlled trial. In accordance with most previous studies,12 13 15 16 17 18 19 20 21 we chose a cluster design as the intervention was implemented in a team setting and to minimise contamination between the intervention and control groups. The study protocol has been published,22 and the data collection procedures and definitions used follow international guidelines for surveillance of football injuries.23 24
We recruited clubs from the female under 14 to under 18 series (age 12-17 years) in eight regional districts of the Swedish Football Association (Blekinge, Bohuslän, Skåne, Småland, Södermanland, Västmanland, Örebro, and Östergötland), all located in the middle and southern parts of Sweden for logistical reasons. After obtaining enrolment registries for the 2009 campaign, two authors (MW and MH) contacted eligible coaches between December 2008 and February 2009. We excluded clubs that did not respond to the invitation or declined participation, those that had fewer than two training sessions a week, and those already using an injury prevention programme.
We randomised all clubs that agreed to participate into an intervention or control group. We used a computer generated list of random numbers to randomise clubs stratified by district, whereby all teams from the same club were assigned to the same group. We chose stratification by district to account for variations in league systems (for example, by competitive or age level) between districts. One author (IA) who was blinded to the identity of the clubs did the randomisation. The randomisation procedure aimed to achieve a balanced number of clubs in the intervention and control groups, considering that the clubs had different number of teams. Randomisation was revealed after recruitment of the final club to ensure concealment of allocation.
Our intervention was a neuromuscular warm-up programme (Knäkontroll, SISU Idrottsböcker, Sweden, 2005) containing exercises focusing on knee control and core stability similar to other programmes in, for example, team handball at that time.25 The six exercises were a one legged knee squat, a pelvic lift, a two legged knee squat, the bench, the lunge, and jump/landing technique.22 Each exercise is subdivided into four steps of progressive difficulty and a pair exercise (table 1⇓). The exercises were preceded by 5 minutes of low intensity running and took about 15 minutes to complete after familiarisation. The intervention clubs were instructed to do the exercises during the warm-up at two training sessions a week throughout the whole season. All players started on the first level of difficulty and proceeded to the next level when exercises were performed with good control as assessed by the coach.
Study procedures and outcomes
We recruited 68 physiotherapists (study therapists) and eight physicians (study physicians) to serve as medical support to the clubs. The study therapists assisted coaches with data collection and recorded injuries in the two groups. The study physicians assisted the study therapists in diagnosing injuries. Two authors (MW and MH) held instructional regional meetings for coaches in both groups in each district, briefing them about the study procedures. Thereafter, a study therapist gave practical instructions about the exercises to one coach and a player from each team in the intervention clubs. Each coach also received a CD-ROM and a leaflet describing the programme. Coaches who could not attend the meetings were given the same verbal and written information by their study therapist before the start of the trial, and coaches in the intervention group also received the practical exercise instructions. During the practical demonstration of the exercises, study therapists instructed the coaches carefully on how to clear players to progress to the next level of difficulty—that is, when all repetitions were performed with good neuromuscular control, mainly focusing on core stability and proper knee alignment. Control group coaches were instructed to train and play as usual throughout the 2009 season without any changes.
We collected data during the competitive season (1 April to 31 October 2009). Injury surveillance included a baseline questionnaire, players’ attendance, and injury registration. The baseline questionnaire included name, social security number, anthropometrics, menarche, previous acute knee injuries, current knee complaints, and family history of anterior cruciate ligament injury. The coach registered individual playing time (registered as minutes of actual participation for each player) and absences (due to acute knee injury or other reasons) for each training session and match during the season on a computer based player’s attendance form and emailed the data monthly to the study therapist and authors (MW and MH). If a player had additional playing time with a district or national team or another team within the club, this was also registered on the attendance form. Participation in other sports or leisure time activities was not recorded. The coach reported acute knee injuries to the study therapist, who evaluated the injury in person and documented it on an injury report form. A recordable acute knee injury was one that occurred during football training or match play, had a sudden onset, and led to a player being unable to participate fully in future training or match play (excluding contusions).22 A severe injury was one that caused absence of more than four weeks. We regarded injuries as non-contact if they occurred without contact with another player or object (excluding the playing surface).22 We defined an anterior cruciate ligament injury as a first or recurrent partial or total rupture of the ligament either in isolation or associated with concomitant injuries to the knee joint.5 If an anterior cruciate ligament injury was suspected or the diagnosis was unclear from the study therapist’s examination, the player was referred to a study physician for further evaluation. Players with possible anterior cruciate ligament injury were offered examination with magnetic resonance imaging. Use of magnetic resonance imaging was not mandatory to confirm other knee injuries if anterior cruciate ligament injury could be ruled out clinically. If any information was missing or was unclear, we contacted the coach or player for further clarification.
The coaches, players, and study therapists were not blinded to group allocation, but the study physicians who assessed the primary outcome were. Two authors (PW and IA) who were not involved in the intervention or data collection did the intention to treat analysis with group identity concealed.
The coaches in the intervention group documented the execution of the warm-up programme on the players’ attendance forms for each training session. Study therapists made two unannounced visits to each intervention team to monitor compliance and execution of the programme. We instructed the therapists to observe the beginning of the training session out of sight of the on-field coach. After having observed the execution of the warm-up programme, the therapists corrected any training errors. Except for these two unannounced visits, no other supervision of coaches was carried out.
The primary outcome was the rate of anterior cruciate ligament injury; secondary outcomes were the rates of severe knee injury and any acute knee injury.22 We did the pre-trial sample size calculation without accounting for clustering and based it on an annual/seasonal incidence of anterior cruciate ligament injury of 1.15% in female adolescent football players.22 With a power of 80% and an estimated reduction of anterior cruciate ligament injury by 50% in the intervention group, we aimed to recruit 8118 players (4059 in each group).
The unadjusted intention to treat analysis used Cox regression with robust standard error estimation to estimate the rate ratio between groups and corresponding 95% confidence interval, in accordance with Lin and Wei.26 We used the robust standard error estimate to account for the correlation of outcomes within each club. We used Wald’s test to calculate P values. We used the same method to do subgroup efficacy analyses for compliant players (defined as having carried out at least one intervention session a week on average), adjusting for the pre-specified covariates age, menarche, previous acute knee injury, match frequency, and match play with other teams. As a sensitivity analysis, we also analysed the primary outcome by using a shared frailty Cox regression model with club as the frailty effect. We checked for possible deviation from the proportional hazards assumption of the Cox regression model by using the non-proportionality test on the basis of the Schoenfeldt residuals.
We calculated the absolute rate reduction with 95% confidence interval for the primary outcome as a crude estimate of the rate difference by using the Mantel-Haenszel method according to Greenland and Rothman.27 This corresponds to a standardised rate difference with weights that depend on the number of player hours in the intervention and control groups of each stratum. In contrast to the Cox regression, this method makes the simplifying assumption that the rate is constant over time in each group. We calculated the number needed to treat for the primary outcome as the inverted absolute rate reduction. We estimated the intra-cluster correlation coefficient for the primary outcome by using generalised estimating equations assuming an exchangeable correlation structure, Poisson distribution, and a log link function. We stratified all analyses by district because of the stratification of the randomisation procedure. We did no interim analyses. We used mean (standard deviation) to make between group comparisons for anthropometric data and exposures. We calculated time to medical attention as median (interquartile range). All tests were two sided with a significance level of <0.05. We used Stata version 11.0 for analyses.
The target population consisted of 414 eligible clubs that we approached for recruitment; 309 clubs (range 1-5 teams in each club) accepted and were randomised into intervention and control groups (figure⇓). Shortly after randomisation, 18 (6%) clubs were dissolved before entering league play owing to a shortage of players. Excluding these clubs, the dropout frequency was 21% (intervention 16% (23/144 clubs), control 26% (38/147 clubs)). We obtained consent for 4564 players, and 65 players declined participation. The players in the two groups who completed the study were similar in terms of baseline characteristics (table 2⇓).
Acute knee injuries
During 278 298 football hours (intervention 149 214 hours, control 129 084 hours), 96 knee injuries (intervention 49, control 47) in 92 players (intervention 48, control 44) were recorded. Twenty-one anterior cruciate ligament injuries occurred in 21 (0.46%) players, of whom 7 (0.28%) were in the intervention group and 14 (0.67%) were in the control group (table 3⇓). Fifty-seven severe knee injuries (22 collateral ligament or capsular sprains, 21 anterior cruciate ligament injuries, 7 patella dislocations or subluxations, 6 meniscus or chondral lesions, and 1 tibia plateau fracture) occurred in 57 players (intervention 26, control 31). No injury occurred during the execution of the warm-up programme.
The medical support supplied to the clubs evaluated 86 (90%) of the 96 injuries. Eight injuries were treated at a local emergency department without notification of the study therapist at occurrence of the injury. Two injured players did not seek medical attention at the time of injury, and the diagnoses were based on study therapists’ examinations and players’ interviews after return to play. The median elapsed time from injury to examination by the study’s medical support was 4 (interquartile range 2-8) days; for anterior cruciate ligament injuries it was 3 (2-6) days. Magnetic resonance imaging or arthroscopy was done for 20 of the 21 anterior cruciate ligament injuries and for 36 of the 57 severe injuries.
Effectiveness of neuromuscular warm-up programme
The unadjusted Cox regression according to intention to treat showed a statistically significant 64% reduction in the rate of anterior cruciate ligament injury in the intervention group compared with the control group (rate ratio 0.36, 95% confidence interval 0.15 to 0.85, P=0.02) (table 4⇓). The sensitivity analysis, using a shared frailty Cox regression model, yielded almost identical results (rate ratio 0.36, 0.14 to 0.91, P=0.03). We detected no statistically significant deviation from the proportionality assumption for the Cox regression model (P=0.232). The estimated intra-cluster correlation coefficient for the primary outcome was negative (−0.0026) and hence given the value 0. The absolute rate difference for the primary outcome was −0.07 (95% confidence interval −0.13 to 0.001) per 1000 playing hours in favour of the intervention group, and the corresponding number needed to treat was 14.
We found no significant rate reductions for secondary outcomes (table 4⇑). The adjusted subgroup analyses of compliant players (1303 players in 112 intervention group clubs, 1967 players in 106 control group clubs) showed a statistically significant 83% rate reduction in anterior cruciate ligament injury (rate ratio 0.17, 0.05 to 0.57, P=0.004), as well as significant reductions for secondary outcomes in the intervention group compared with the control group (severe knee injury rate ratio 0.18, 0.07 to 0.45, P<0.001; any acute knee injury rate ratio 0.53, 0.30 to 0.94, P=0.03). Finally, exploratory analyses of non-contact anterior cruciate ligament injuries showed a reduction in rates favouring the intervention group. The reduction was statistically significant only for the adjusted subgroup analysis of compliers (intention to treat analysis rate ratio 0.40, 0.13 to 1.18, P=0.10; adjusted subgroup analysis rate ratio 0.26, 0.07 to 0.99, P=0.049).
The principal finding in this cluster randomised controlled trial was that a 15 minute neuromuscular warm-up programme reduced the overall rate of anterior cruciate ligament injury in adolescent female football players by 64%. Additionally, we saw a preventive effect for severe knee injury and any acute knee injury in players who completed the programme at least once a week (compliers).
Prevention of knee injury
Of the previous controlled studies that evaluated neuromuscular training programmes in adolescent female football players,12 14 15 16 17 18 19 20 only two non-randomised studies have shown preventive effects—one on hospital treated acute knee injuries and the other on non-contact anterior cruciate ligament injuries.16 17 However, most previous studies were too small to show preventive effects on knee injuries, and this, together with poor compliance by players, might have been an important reason why they failed to show an effect. We found a reduction in the overall rate of anterior cruciate ligament injury by almost two thirds according to a stratified Cox regression model, and the result was replicated in a sensitivity analysis. The number needed to treat was 14, meaning that for every 14 players who receive the warm-up programme one less anterior cruciate ligament injury would occur per 1000 playing hours. However, as the absolute rate difference according to the Mantel-Haenszel method did not reach statistical significance, the number needed to treat should be interpreted with caution.28 We believe that the main reason for the discrepancy between the statistically significant rate ratio from the Cox regression model and the non-significant absolute rate difference according to the Mantel-Haenszel method is that this last method, besides the constant rate assumption, can exhibit lower statistical precision.27 We chose the Mantel-Haenszel method in spite of this drawback, as it is recommended to avoid possible bias when the number of events is low.27
In accordance with previously evaluated neuromuscular programmes, the exercises evaluated in this study targeted leg and core muscles, balance, landing technique, and proper knee alignment. The rationale for including such exercises in prevention programmes for anterior cruciate ligament injury is that lateral trunk displacement and excessive dynamic knee valgus have been found to be risk factors for this type of injury.29 30 Because most anterior cruciate ligament injuries in football players are believed to result from non-contact injury mechanisms,5 neuromuscular preventive programmes have primarily targeted non-contact injuries. However, having proper neuromuscular control might also help to protect the knee from injury after a gentle push to the trunk or a fair shoulder to shoulder tackle. We therefore chose to include all anterior cruciate ligament injuries regardless of mechanism of injury as the primary outcome in our trial. In an exploratory analysis of non-contact anterior cruciate ligament injury, we found no significant effect (P=0.10) even though the point estimate (rate ratio 0.40) suggests a reduction of the same magnitude as for the primary outcome. Interestingly, five of the anterior cruciate ligament injuries occurred during football training, all of which were non-contact in nature and occurred in the control group. This suggests that non-contact anterior cruciate ligament injuries during training may be preventable with the neuromuscular training programme. The finding is consistent with a previous study on female collegiate football players, in which the preventive effect was seen only for training related anterior cruciate ligament injuries.13
Strengths and limitations of study
To our knowledge, this study is the largest randomised controlled trial of injury prevention in sports to date, involving more than 4500 players. Some important strengths of the trial include cluster randomisation of clubs to avoid contamination between the intervention and control groups, individual playing time registration with no missing data for analysed clubs, careful monitoring of compliance, blinded analysts, and no involvement of the authors in the development of the programme. Additionally, the medical support supplied through the study enabled quick and qualified examination of injuries by experienced sports medicine practitioners, and the study physicians who verified the primary outcome were blinded to group allocation.
This trial also has some limitations. Firstly, the estimation of the sample size was not based on a conventional calculation for cluster randomised controlled trials, as valid data for rates of anterior cruciate ligament injury based on playing time, and corresponding intra-cluster correlation coefficients, in adolescent female football players were lacking in the literature.22 Consequently, estimating the intra-cluster correlation coefficient and the inflation factor a priori was difficult. Secondly, we did not recruit the estimated sample according to our sample size calculation, as the number of clubs that were excluded before randomisation (105 clubs), that were dissolved shortly after randomisation owing to shortage of players (18 clubs), or that dropped out during the season (61 clubs) was higher than expected. A lower than expected seasonal incidence of anterior cruciate ligament injury (0.67% v 1.15% according to pre-trial sample size calculation) also contributed to a limited number of anterior cruciate ligament injuries being recorded. However, we believe that the number of players included achieved the purpose of the study, even though we acknowledge that a larger sample would have added further strength to our study.
Thirdly, a possibility of selection bias exists because clubs that initially chose to participate (and intervention clubs that continued through the whole study period) may have been more motivated to follow the neuromuscular training regime than clubs that did not respond to the invitation, declined participation, or dropped out during the study. Although providing a reason for leaving the study was not necessary (according to research ethics), a plausible factor contributing to the high dropout frequency might be unwillingness to complete the individual playing time registration, as this puts substantial strain on the recorders. In line with findings in other recent trials on adolescent football players,12 19 20 the dropout frequency was higher in the control group, possibly indicating disappointment with group allocation. Fourthly, we have no data on the number of players in the non-participating clubs, as reliable statistics on the number of eligible players in each district in the target age groups were lacking. However, on the basis of the average squad size of the participating clubs, we estimate that approximately 6500 players were randomised in the trial.
Fifthly, the study therapists had several assignments, including monitoring compliance and evaluating knee injuries, and they were thus not blinded to group allocation. However, recruitment of additional physiotherapists specifically to examine the knee injuries was not possible. Sixthly, we set the cut-off threshold for players’ compliance at performance of at least one intervention session a week. This is arguably rather low, but it was based on the fact that most clubs had two weekly training sessions; and a recent Norwegian trial on adolescent female football players reported average attendance of around 60%, and the average player’s compliance in the intervention group in that study was 0.8 sessions a week.19 All compliance data were reported by coaches on the players’ attendance forms, but we were unable to validate the coaches’ reports except for the two unannounced visits by the study therapists. Furthermore, the progression of the exercises was done under the supervision of the coach without any guidance by the study therapists during the season, and the extent to which the intervention clubs used the programme with fidelity and progressed through the programme as intended is uncertain. We chose this approach to resemble a real world situation, where no such external professional resources would be available to youth football clubs.
Finally, we had no control over whether any of the control group clubs performed exercises similar to our intervention programme during the study period, despite coaches having stated at study inclusion that they did not do any such exercises and the fact that they were instructed to carry out their usual training as normal during the season without any changes. However, any possible bias introduced by such contamination of the control group would lead to underestimation of the preventive effect found in our study.
Implications and applicability
The number of female football players, a high risk group from a knee injury perspective, is growing rapidly worldwide. Successful preventive measures in football could thus have a substantial effect on the injury burden and also dramatically diminish the costs associated with treatment. The direct costs of surgery and hospital care for anterior cruciate ligament reconstructions are high,31 32 and additional costs are associated with non-surgical treatment, postoperative rehabilitation, and disability claims. Consequently, if almost two thirds of the anterior cruciate ligament injuries in adolescent female football players were avoided, this would substantially reduce the need for surgery and rehabilitation with large health economic benefits. Future efforts should include cost-benefit analyses of neuromuscular training programmes, as well as implementation research identifying motivators and barriers (among coaches and players) to adoption of such training programmes.
Whether our results can be generalised to other age groups, male football players, or other team sports is uncertain. However, similar neuromuscular programmes have shown preventive effects in other cluster randomised controlled trials for training related anterior cruciate ligament injuries in female collegiate football players,13 as well as on lower extremity injury in adolescent female football players,19 team handball players (mainly female),25 and adult female floorball players.33 Therefore, assuming that the programme might be also effective in other football populations as well as in other sports is reasonable.
What is already known on this topic
Knee injuries are common in football regardless of the playing level, and adolescent female players are more susceptible to anterior cruciate ligament injury than their male counterparts
Several parallel group controlled studies have evaluated different injury prevention strategies in adolescent female football players
However, few studies have shown statistically significant reductions of knee injury or anterior cruciate ligament injury with neuromuscular training
What this study adds
A 15 minute neuromuscular warm-up programme reduced the overall rate of anterior cruciate ligament injury by 64% in adolescent female football players
Players who carried out the programme at least once a week (compliers) additionally had lower rates of severe knee injury (>4 weeks’ absence) and any acute knee injury
Neuromuscular training should be part of the warm-up programme for young female football players
Cite this as: BMJ 2012;344:e3042
We thank the study assistants from the Swedish Football Association (Per Renström, professor, Annica Näsmark, physiotherapist, and Anneli Gustafsson, football coach) for their general help with the study, and Jonas Ranstam, senior bio-statistician, for statistical advice. We also thank the coaches and all players who participated in the study, as well as the study therapists and study physicians.
Contributors: MW, IA, and MH were responsible for the conception and design of the study. MW and MH coordinated the study and managed all aspects, including data collection. HM provided technical support and was responsible for database management. PW did the analyses, which were planned and checked with the other authors. MW, IA, and MH wrote the first draft of the manuscript. All authors had full access to all data and contributed to interpretation of the findings and critical revision of the manuscript. MW and MH are the guarantors.
Funding: The study was financially supported by the Swedish Football Association and the Folksam Insurance Company. This research also received grants from the Swedish National Centre for Research in Sports and from the Hässleholm Hospital. None of the sponsors had any role in the design or conduct of the study; the collection, analysis, and interpretation of the data; or the preparation, approval, and submission of the manuscript. No author or related institution has received any financial benefit from research in this study.
Competing interests: All authors have completed the Unified Competing Interest form at www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare: MW, HM, and MH had financial support from the Swedish Football Association and the Folksam Insurance Company; MW and MH received research grants from the Swedish National Centre for Research in Sports and IA received a grant from the Hässleholm Hospital for the submitted work; MW and MH have been paid by the Swedish Football Association for constituting the medical staff of the Swedish male under 19 national team; no other relationships or activities that could appear to have influenced the submitted work.
Ethical approval: The study was approved by the regional ethical review board in Linköping (M197-08). Players and parents or guardians gave individual written informed consent.
Data sharing: No additional data available.
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