Don’t let misinformation derail the trachoma elimination programmeBMJ 2012; 344 doi: http://dx.doi.org/10.1136/bmj.e2579 (Published 10 April 2012) Cite this as: BMJ 2012;344:e2579
- Anthony W Solomon, lecturer1
- On behalf of David C W Mabey, professor; Clare Gilbert, professor; Ulla Griffiths, lecturer; Anne Mills, professor; Allen Foster, professor (London School of Hygiene and Tropical Medicine, UK); Sheila K West, professor (Wilmer Eye Institute, Johns Hopkins University, USA); Paul Courtright, director (Kilimanjaro Centre for Community Ophthalmology, Tumaini University, Tanzania) Joseph Feczko, former chief medical officer (Pfizer, USA); Wondu Alemayehu, consultant (Berhan Public Health and Eye Care Consultancy, Ethiopia); Catherine Cross, prevention of blindness consultant (UK); Thomas M Lietman, professor (Francis I Proctor Foundation, University of California San Francisco, USA); Danny Haddad, director (International Trachoma Initiative, Task Force for Global Health, USA); Caroline Harper, chief executive officer (Sightsavers, UK); Paul Emerson, director of trachoma programs (Carter Center, USA); Richard Le Mesurier, medical director (Fred Hollows Foundation, Australia); Peter Ackland, chief executive officer (International Agency for the Prevention of Blindness, UK); Dirk Engels, coordinator (Preventive Chemotherapy for Neglected Tropical Diseases, WHO, Switzerland); Silvio P Mariotti, ophthalmologist (WHO Alliance for the Global Elimination of Trachoma by 2020, Switzerland)
Firstly, “mass treatment with azithromycin” for trachoma was defined as azithromycin treatment for all children aged 1-10 years,3 whereas the World Health Organization recommends treatment of all residents.
Secondly, data from a 1998-9 western Nepal trial were extrapolated to estimate effectiveness of mass treatment throughout sub-Saharan Africa and South East Asia.
Thirdly, the model’s coverage level parameter “does not affect the reduction in the prevalence of active trachoma”3; we doubt that this is true.
Fourthly, disability weights were assigned only for the outcomes visual impairment and blindness.3 Trichiasis has considerable physical, social, and economic effects from its onset, not just after low vision ensues. Furthermore, active trachoma was denied a disability weight, and the ancillary savings in disability adjusted life years (DALYs) of mass azithromycin treatment (which may include reduced all cause mortality in children4) were ignored.
Fifthly, WHO and partners aim to eliminate trachoma as a public health problem by 2020. An elimination programme derives positive externalities (in economic terms) from protection of future generations. It is a mistake to assess infectious diseases in the same way that cataract is assessed.
Lastly, costs were assigned for azithromycin purchase using a theoretical price.2 Azithromycin for trachoma control is donated by the manufacturer.
On the basis of analyses that are flawed on both sides of the cost effectiveness equation, Chisholm and colleagues concluded that saving a DALY with mass azithromycin treatment in trachoma endemic areas of sub-Saharan Africa or South East Asia costs more than the per capita gross domestic product of each region. International commitment to trachoma control has never been stronger,5 and it would be tragic for poor communities affected by trachoma if programme momentum was lost through misinformation.
Cite this as: BMJ 2012;344:e2579
Competing interests: AF, AWS, SKW, PC, JF, WA, and CC are the chair and members of the International Trachoma Initiative’s Expert Committee. AWS, DCWM, AF, SKW, and PC have received research grants from the International Trachoma Initiative and/or Pfizer, the manufacturer of azithromycin.
This is a shortened version of a rapid response, which appears in full at: www.bmj.com/content/344/bmj.e586/rr/575171.