Sequential trialsBMJ 2012; 344 doi: http://dx.doi.org/10.1136/bmj.e2102 (Published 21 March 2012) Cite this as: BMJ 2012;344:e2102
- Philip Sedgwick, senior lecturer in medical statistics
- 1Centre for Medical and Healthcare Education, St George’s, University of London, Tooting, London, UK
Researchers investigated whether “collaborative requesting” increased consent rates for organ donation from relatives of patients meeting criteria for brain stem death. A randomised controlled trial using a sequential design was performed. Collaborative requesting is when the patient’s clinician and a donor transplant coordinator (organ procurement officer) make a joint request for a donation. The control intervention was the routine request by the clinical team. The primary outcome was consent for organ donation. In total, 201 relatives were recruited from intensive care units. It was reported that collaborative requesting did not significantly affect consent rates when compared with routine requesting.1
Which of the following statements, if any, are true?
a) Relatives were recruited sequentially, as is intrinsic to the design of sequential trials.
b) Sequential …
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