MinervaBMJ 2011; 343 doi: https://doi.org/10.1136/bmj.d8039 (Published 14 December 2011) Cite this as: BMJ 2011;343:d8039
The Gleason grading system for prostate cancer assigns a high score to patients with a poor prognosis, yet a substantial number of patients with low scores still develop aggressive cancers. A Swedish team used genetic microarray analysis to collate genetic signatures of a range of tumour characteristics, creating unique molecular profiles. Using these profiles, they identified five subtypes of prostate cancer on the basis of distinct prognostic outcomes. Two of these subtypes counted for 11% and 18% of patients with poor prognoses but low Gleason scores. The team says its work may help identify such patients at the time of diagnosis (Proceedings of the National Academy of Sciences 2011, doi:10.1073/pnas.1117029108).
Short people appear to draw the short straw when it comes to receiving lung protective ventilation (LPV) to enhance survival for acute lung injuries. Researchers analysed the records of a US cohort of 421 patients with severe sepsis related lung injuries. Women received LPV less frequently than men, but after adjusting for height and the severity of …
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