BMJ 2011; 343 doi: https://doi.org/10.1136/bmj.d7681 (Published 30 November 2011) Cite this as: BMJ 2011;343:d7681

After heart attacks, two types of drugs are commonly prescribed: antiplatelet treatment and selective serotonin reuptake inhibitors (SSRI) for depression. A retrospective analysis of patients discharged after acute myocardial infarction over 10 years found that compared with aspirin alone, the combined use of an SSRI and antiplatelet therapy resulted in a higher risk of bleeding. The combination of two antiplatelet agents plus SSRI also increased the risk of bleeding compared with dual antiplatelet therapy alone (CMAJ 2011;183:1835-43, doi:10.1503/cmaj.100912).

Cemented or cementless; apparently, it doesn’t matter in knees. A cohort of 52 patients who underwent simultaneous bilateral total knee replacement with identical prostheses—one cemented, the other non-cemented—were followed up for an average of 13.6 years. At the final review there were no significant differences between the groups in mean Knee Society scores, osteoarthritis indices, ranges of knee movement, patient satisfaction, or radiological results. Survival rates of the femoral components were 100% in both groups at 14 years, while cemented tibial components survived marginally better than non-cemented. No osteolysis was identified in either group (Journal of Bone and Joint Surgery 2011;93-B:1479-86, …

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