Authors’ reply to Graudal and JürgensBMJ 2011; 343 doi: http://dx.doi.org/10.1136/bmj.d6121 (Published 27 September 2011) Cite this as: BMJ 2011;343:d6121
- Francesco P Cappuccio, Cephalon professor of cardiovascular medicine and epidemiology, head of WHO collaborating centre1,
- Simon Capewell, chair of clinical epidemiology2,
- Paul Lincoln, chief executive3,
- Klim McPherson, visiting professor of public health epidemiology4
- 1University of Warwick, Warwick Medical School, WHO Collaborating Centre for Nutrition, Coventry CV2 2DX, UK
- 2University of Liverpool, Liverpool, UK
- 3National Heart Forum, London, UK
- 4University of Oxford, Oxford, UK
Graudal and Jürgens’s first statement is incorrect.1 The TOHP Trial, for example, was carried out on a background of a contemporary American diet with an average baseline daily sodium intake of 150-180 mmol. An average moderate reduction of 33-44 mmol/day reduced cardiovascular disease outcomes by 52% and 21% and all cause mortality by 24% and 17% at 18 months and 3-4 years, respectively.
The Belgian study achieved no difference in salt intake, so unsurprisingly no effect was seen on measured …
Log in using your username and password
Log in through your institution
Register for a free trial to thebmj.com to receive unlimited access to all content on thebmj.com for 14 days.
Sign up for a free trial