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Taking non-aspirin NSAIDs in early pregnancy doubles risk of miscarriage, study shows

BMJ 2011; 343 doi: https://doi.org/10.1136/bmj.d5769 (Published 09 September 2011) Cite this as: BMJ 2011;343:d5769
  1. Barbara Kermode-Scott
  1. 1Montreal

The risk of miscarriage among women who took any type and dosage of non-steroidal anti-inflammatory drug (NSAID), excluding aspirin, in early pregnancy is more than double that among pregnant women who did not, concludes a new study published in the journal of the Canadian Medical Association (CMAJ doi:10.1503/cmaj.110454).

The principal investigator, Anick Bérard, professor in the Faculty of Pharmacy at the University of Montreal, said, “We consistently saw that the risk of having a spontaneous abortion was associated with gestational use of diclofenac, naproxen, celecoxib, ibuprofen, and rofecoxib alone or in combination, suggesting a class effect. We did not see a dose-response …

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