BMJ 2011; 342 doi: http://dx.doi.org/10.1136/bmj.d770 (Published 08 February 2011) Cite this as: BMJ 2011;342:d770

A study investigated whether individual clinical and psychological risk factors for coronary artery disease correlated with coronary atherosclerosis, as assessed by coronary artery calcium (CAC). In three cohorts of healthy, asymptomatic, and symptomatic people no association was seen between these factors and CAC scores, except for a small negative correlation with depression in symptomatic patients. The findings cast doubt on the use of CAC as a surrogate marker in assessing the clinical importance of risk factors (Psychosomatic Medicine 2011;73:7-15, doi:10.1097/PSY.0b013e3181fd94f5).

A Danish team has tried to distinguish whether de novo mutations in paternal germ cells are responsible for the increased risk of schizophrenia with greater paternal age, or whether late fatherhood produces a predisposition to schizophrenia in children. Its analysis found that the father’s age when his first child is born seems to have a greater influence on the risk of schizophrenia than the father’s …

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