Preventing exacerbations in chronic obstructive pulmonary diseaseBMJ 2011; 342 doi: https://doi.org/10.1136/bmj.d761 (Published 03 February 2011) Cite this as: BMJ 2011;342:d761
Several readers have pointed out that this Clinical Review article contained some outdated definitions on the grades of severity of airflow obstruction (BMJ 2011;342:c7207, doi:10.1136/bmj.c7207). This article was first published in Drug and Therapeutics Bulletin (DTB) in July 2010 (DTB 2010;48:74-7, http://dtb.bmj.com/content/48/7/74.abstract) and reprinted in the BMJ in January 2011. The definitions given in the article were cited as being from the 2010 guideline from the National Institute for Health and Clinical Excellence (NICE) on chronic obstructive pulmonary disease. However, the updated (2010) NICE guideline was published during the final stage of the production of the DTB article, and although the article text was amended to reflect the revised NICE recommendations on management of exacerbations, NICE’s revised definitions of severity of airflow obstruction were mistakenly not included in the DTB article or in the subsequent reprinted version in the BMJ. The article therefore defined mild airflow obstruction in chronic obstructive pulmonary disease as a forced expiratory volume in one second (FEV1) of 50-79% predicted, moderate as 30-49%, and severe as below 30%, whereas the NICE 2010 guideline defines mild chronic obstructive pulmonary disease as a post-bronchodilator FEV1 of at least 80% predicted, moderate as 50-79%, severe as 30-49%, and very severe as <30%. This error does not affect any of the DTB article’s own recommendations.
Cite this as: BMJ 2011;342:d761