Letters Paracetamol

Author’s reply

BMJ 2011; 342 doi: https://doi.org/10.1136/bmj.d628 (Published 01 February 2011) Cite this as: BMJ 2011;342:d628
  1. Lee C Claridge, Wellcome Trust clinical research fellow1
  1. 1Centre for Liver Research, University of Birmingham, Birmingham, UK
  1. l.c.claridge{at}bham.ac.uk

Hoffman questions the cause of liver failure in the cases we described.1 Patient 1 weighed 30 kg because of chronic malnutrition secondary to Crohn’s disease, which increased his susceptibility to paracetamol induced hepatotoxicity. The second patient’s rapid onset of liver failure, with serum aspartate aminotransferase peaking at over 7000 …

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