MinervaBMJ 2011; 342 doi: http://dx.doi.org/10.1136/bmj.d3807 (Published 22 June 2011) Cite this as: BMJ 2011;342:d3807
Long term treatment with lithium may have beneficial effects on cognitive function. Forty five patients with amnestic mild cognitive impairment were randomised to receive lithium or placebo over 12 months in a double blind trial. Lithium was associated with a significant decrease in concentrations of phosphorylated-tau in the cerebrospinal fluid and better performance on the cognitive subscale of the Alzheimer’s disease assessment score and in attention tasks. Tolerability was good and the adherence rate was 91% (British Journal of Psychiatry 2011;198:351-6, doi:10.1192/bjp.bp.110.080044).
A large systematic review of randomised trials examined the effect of supplementation with multiple micronutrients, compared with iron and folic acid supplements, on pregnancy outcomes in less developed countries. It reports that multiple micronutrient supplementation was more effective at reducing the risk of low birth weight and small size for gestational age. But it offered no overall effect on perinatal mortality, although further analyses …
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