Trial of niacin alongside statin is stopped earlyBMJ 2011; 342 doi: https://doi.org/10.1136/bmj.d3400 (Published 31 May 2011) Cite this as: BMJ 2011;342:d3400
- Jacqui Wise
The US National Institutes of Health has stopped a clinical trial studying a combination of niacin (nicotinic acid) and a statin 18 months earlier than planned because of poor results.
The AIM-HIGH trial found that adding high dose, extended release niacin to a statin in patients with heart and vascular disease did not reduce the risk of cardiovascular disease and stroke. In fact there was a small and unexplained increase in ischaemic stroke rates among those receiving the combination treatment.
The randomised controlled trial involved 3414 patients in the United States and Canada with a history of cardiovascular disease who were already taking a statin drug to lower low density lipoprotein (LDL) cholesterol levels. The average age of the participant was 64 years and more …