Letters Rosiglitazone saga

Should we throw the baby out with the bathwater?

BMJ 2011; 342 doi: https://doi.org/10.1136/bmj.d2566 (Published 21 April 2011) Cite this as: BMJ 2011;342:d2566
  1. Charlotte McDonald, associate professor of medicine
  1. 1Division of Endocrinology, Department of Medicine, University of Western Ontario, London, ON, Canada N6A 4V2
  1. charlotte.mcdonald{at}sjhc.london.on.ca

The authors disapprove of doctors who prescribe thiazolidinediones but still advocate for “tight” glycaemic control.1

“Tight” control (7% glycated haemoglobin (HbA1c)) did not lead to increased mortality in the UKPDS.2 “Very tight” glycaemic control in ACCORD was associated with a small increase in mortality, for reasons unknown,3 but the results cannot be generalised to patients with newer onset diabetes. Some guidelines now …

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