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From Systems Science perspective and its Dynamic Systems Model,
osteoarthritis, as a degenerative disease, can be viewed as an expression
of a bodily system that has entered and is decelerating in the Zone of
Entropy. The diminishing physical activity, inflammation, etc. are all
features that reflect progressive accumulation of non-functionality, a key
feature of the approaching bodily system's final denouement. The increase
in all-cause mortality, preceded by disability, objectively charts the
course of human body through entropy.
Janecka IP: Cancer control through principles of systems science,
complexity, and chaos theory: A model. Int J Med Sci 2007; 4:164-173. http://www.medsci.org/v04p0164.htm