BMJ 2010; 341 doi: http://dx.doi.org/10.1136/bmj.c6109 (Published 03 November 2010) Cite this as: BMJ 2010;341:c6109

Depressed people react more strongly to signs of disgust than healthy people, according to a small functional magnetic resonance imaging study. The test involved judging the gender of facial identities displaying different degrees of fear, disgust, or no emotion. Compared with the nine healthy people who acted as controls, the nine depressed patients all displayed greater activation in their brain when faced with disgust (Journal of Psychiatric Research 2010;44:894-902, doi:10.1016/j.jpsychires.2010.02.010).

Melatonin looked like it might be useful as prophylaxis against migraine, because a large proportion of people with migraine who took it regularly at night reported substantially reduced headaches and better sleep. But a randomised controlled trial in Neurology has failed to find any difference between prolonged release melatonin and placebo taken before bedtime for eight weeks in terms of reducing migraines (2010;75:1527-32, doi:10.1212/WNL.0b013e3181f9618c).

The effect of …

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