Bridging theory and reality gapBMJ 2010; 341 doi: https://doi.org/10.1136/bmj.c4698 (Published 07 September 2010) Cite this as: BMJ 2010;341:c4698
- Chengxuan Qiu, senior researcher1
- 1Aging Research Center, Karolinska Institutet, Gdvlegatan 16, 11330 Stockholm, Sweden
Ritchie and colleagues may be overoptimistic about their programmes to prevent dementia1 given the huge gap between theoretical programmes derived from observational studies and findings from randomised clinical trials.
Indeed, observational studies have frequently shown an association of dementia with several modifiable factors—hypertension, hyperlipidaemia, and diabetes being putative risk factors …