Letter

Fever as nature’s engine

Part of beneficial host response?

BMJ 2010; 340 doi: 10.1136/bmj.c450 (Published 26 January 2010)
Cite this as: BMJ 2010;340:c450

This article has a correction

Please see: Part of beneficial host response?

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  1. Garth Dixon, consultant microbiologist and honorary senior lecturer1,
  2. Clare Booth, research assistant2,
  3. Elizabeth Price, honorary consultant microbiologist3,
  4. Roger Westran, senior biomedical scientist3,
  5. Malcolm Turner, professor of molecular immunology2,
  6. Nigel Klein, professor of infection and immunity1
  1. 1Infectious Diseases and Microbiology Unit, Institute of Child Health, University College London, London WC1N 1EH
  2. 2Immunobiology Unit, Institute of Child Health, University College London, London WC1N 1EH
  3. 3Department of Medical Microbiology, Barts and the London NHS Trust, Pathology Pharmacy Building, London E1 2ES
  1. g.dixon{at}ich.ucl.ac.uk

    Fowler comments on the value of a raised temperature to combat flu.1 Fever may also be necessary for optimal defence against bacterial infections.2 We explored this possibility for meningococcal disease.

    We diluted a suspension of an isolate of Neisseria meningitidis B to approximately 109 colony forming units/ml. We inoculated 500 µl suspension into supplemented proteose peptone 9.5 ml in duplicate and incubated one tube of …

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