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Tranexamic acid cuts deaths in trauma patients at risk of major bleeding

BMJ 2010; 340 doi: http://dx.doi.org/10.1136/bmj.c3214 (Published 15 June 2010) Cite this as: BMJ 2010;340:c3214
  1. Philip Wilson
  1. 1BMJ

    Administering tranexamic acid to trauma patients at risk of major bleeding reduces all cause mortality as well as mortality from bleeding, a new trial has found.

    World Health Organization figures give injury as the cause of 5.8 million deaths worldwide each year. The trial estimates that widespread adoption of tranexamic acid as a treatment for trauma could prevent 13 000 deaths a year in India, 12 000 in China, 2000 in the United States, and several hundred in the United Kingdom.

    The trial included 20 000 adults in 40 countries. Trauma victims judged likely to need an early blood transfusion were randomly allocated to receive 1 g of tranexamic acid within eight hours …

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