Waiting times for radiotherapy after breast cancerBMJ 2010; 340 doi: https://doi.org/10.1136/bmj.c1007 (Published 03 March 2010) Cite this as: BMJ 2010;340:c1007
- Ruth H Jack, information analyst1,
- Lars Holmberg, professor of cancer epidemiology2
- 1King’s College London, Thames Cancer Registry, London SE1 3QD
- 2King’s College London, Division of Cancer Studies, Research Oncology, Guy’s Hospital, London SE1 9RT
The effect of the time interval between radiotherapy and surgery on the recurrence of breast cancer has been investigated in several countries. Some studies have indicated a positive association,1 2 whereas others have found no link.3 4 A recent systematic review concluded that an interval of more than eight to 12 weeks between breast conserving surgery and radiotherapy increased local recurrence rates when no other treatment was given.5 However, the review summarised studies that had used different cut-off points for time to radiotherapy, which hampers a straightforward interpretation.
In the linked retrospective cohort analysis (doi:10.1136/bmj.c845), Punglia and colleagues assess whether the interval between breast conserving surgery and radiotherapy affects the risk of local recurrence in women with early stage breast cancer in the United States.6 They found a significantly increased hazard of local recurrence of breast cancer in women who waited more than six weeks for radiotherapy (hazard ratio 1.19, 95% …