Metformin: framed again?BMJ 2009; 339 doi: https://doi.org/10.1136/bmj.b5570 (Published 23 December 2009) Cite this as: BMJ 2009;339:b5570
- David J Preiss, clinical research fellow1,
- Naveed Sattar, professor of metabolic medicine1
- 1BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow G12 8TA
Fitzgerald and colleagues show that metformin treatment should be avoided in acute renal failure,1 but their focus on metformin associated lactic acidosis is misplaced.
Metformin has long been suggested as a cause of lactic acidosis in published case reports, but evidence from large cohorts and meta-analyses of controlled trials remains conspicuously absent.2 Metformin is often …