Mefloquine has more adverse effects than other drugs for malaria prophylaxis

doi:10.1136/bmj.b4167

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Lynn Eaton

¹London

Researchers for the Cochrane Collaboration have found that mefloquine (Lariam) has more adverse effects than the two main alternatives for antimalaria prophylaxis.

They looked at prophylactic regimens for visitors to countries where Plasmodium falciparum has developed resistance to chloroquine (Cochrane Database of Systematic Reviews 2009;(4):CD006491, doi:10.1002/14651858.CD006491.pub2). Their review looked at the efficacy, safety, and tolerability of three regimens: atovaquone-proguanil (Malarone), doxycycline, and mefloquine.

On safety, the authors said that the main problem …