Rapid responses are electronic letters to the editor. They enable our users to debate issues raised in articles published on thebmj.com. Although a selection of rapid responses will be included online and in print as readers' letters, their first appearance online means that they are published articles. If you need the url (web address) of an individual response, perhaps for citation purposes, simply click on the response headline and copy the url from the browser window. Letters are indexed in PubMed.
The best way to prevent premature cardiac disease is to make sure
that the patient is nutritionally adequate.
We face a silent epidemic of Vitamin deficiencies due to over
processed food and kidney failure patients are no exception in fact they
are more at risk because they are not allowed potassium in excess due to
their kidney function. This rules out fresh fruit.
Before the statins there was a cheap, clinically effective way of
lowering bad lipids in the blood Its in the BNF Generic modified release
Niacin. No side effects and a very useful lipid lowering agent.
Vitamin B3 just as effective as statins. It would be interesting and
probably a decent study to organise a double blind trial between these two
agents Simvastatin, and Niacin
Statins competitively inhibit HMG CoA reductase in all cells
including renal cells. Is it a good idea to instigate a drug that would
poison the very functions of the kidney?
The other way to enhance the cardiac function is to add Co enzyme
Q10 or ubiquinone as the heart prefers fatty acids to use as an energy
source and ubiquinone is part of the ornithine cycle providing energy in
(this is all first year medical school biochemistry in action)
Vitamin C and Ubiquinone and Vitamin B3 and you would never need a
statin. Your cholesterol is produced in response to inflammation, which
if you have renal interstitial disease leading to renal failure means that
the body is trying to repair the damage. To add a statin would cause harm.
Statins are not wonder drugs, they disturb the HMG co A reductase in
every cell of the body. Yes thats right every cell, not just the
hepatocytes where cholesterol is made.