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Arthur Conan Doyle takes it to the limit (1879)

BMJ 2009; 339 doi: http://dx.doi.org/10.1136/bmj.b2861 (Published 04 August 2009) Cite this as: BMJ 2009;339:b2861

Some years ago, a persistent neuralgia led me to use the tincture of gelseminum to a considerable extent. I several times overstepped the maximum doses of the text-books without suffering any ill effects. Having recently had an opportunity of experimenting with a quantity of the fresh tincture, I determined to ascertain how far one might go in taking the drug, and what the primary symptoms of an overdose might be. I took each dose about the same hour on successive days, and avoided tobacco or any other agent which might influence the physiological action of …

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