BMJ 2009; 338 doi: http://dx.doi.org/10.1136/bmj.b495 (Published 10 February 2009) Cite this as: BMJ 2009;338:b495

Most people would prefer to take medicine as seldom as possible, and for those with active ulcerative colitis there’s good news: taking 3 g of mesalazine granules once daily works as well as taking 1 g three times a day. The results come from a double blind randomised multicentre international trial, and similar numbers of adverse events occurred in both groups. Endoscopic remission was achieved in about 70% of patients in both groups (Gut 2009;58:23-40, doi:10.1136/gut.2008.154302).

A 3 mm diameter mini tablet may offer a successful formulation for young children. A single placebo mini tablet was given to each of 100 pre-school children attending one hospital by asking them to let their parent place the pill on the back of their tongue, and to then drink lots of water until the pill was in their tummy. The pill was successfully swallowed by 53% of three year olds and …

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