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Study questions benefits of immediate hormone therapy after menopause

BMJ 2009; 338 doi: http://dx.doi.org/10.1136/bmj.b2236 (Published 04 June 2009) Cite this as: BMJ 2009;338:b2236
  1. Roger Dobson
  1. 1Abergavenny

    No evidence shows that hormone therapy started soon after menopause has a beneficial effect, according to a study in the American Journal of Epidemiology (2009 May 25, doi:10.1093/aje/kwp115). The authors found no support for the postmenopausal oestrogen timing hypothesis—that is, that treatment initiated soon after menopause prevents coronary heart disease and that treatment started later has a null or adverse effect.

    The US authors further analysed results from the Women’s Health Initiative randomised controlled trials of 0.625 mg/day of conjugated equine oestrogens (CEE) among 10 739 women after hysterectomy and conjugated equine oestrogens plus 2.5 mg/day of medroxyprogesterone acetate (MPA) among 16 608 women with an intact uterus. The trials were designed to look at the effects …

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