BMJ 2009; 338 doi: http://dx.doi.org/10.1136/bmj.b2112 (Published 26 May 2009) Cite this as: BMJ 2009;338:b2112

A 48 week study of patients with mild cognitive impairment treated with donepezil, an acetylcholinesterase inhibitor, showed no significant improvements in the primary measures of cognition or of global function. And nearly all the measures of global impairment, cognition, and function remained unchanged. The authors suggest that the measures used may be insensitive to change in mild cognitive impairment. Patients, however, reported perceived benefits with donepezil (Neurology 2009;72:1555-61, doi:10.1212/01.wnl.0000344650.95823.03).

High energy war zone trauma, especially in blast injured amputees, lends itself to heterotopic ossification. A retrospective study of US troops from 2003 to 2006 identified a higher prevalence of heterotopic ossification in war wounded patients than in civilians who had sustained trauma. Risk factors in the military include age under 30, the presence of severe brain injury, and multiple injuries to the extremities, which points to systemic causes rather than a single origin (Journal of Bone and Joint Surgery Am 2009;91:1084-91, doi:10.2106/jbjs.h.00792).

Many types of solid cancers have a lower incidence in people with Down’s syndrome than in the general population, and this protection appears to be caused by an extra copy of …

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