- R Pryce, paediatrician
- 1Mildura Base Hospital, Ontario Avenue, Mildura, Victoria 3500, Australia
- bekyp@doctors.org.uk
- Accepted 7 June 2008
Use of continuous subcutaneous insulin infusion is increasing worldwide.1 This method of insulin delivery was thought to have advantages in children, including better control of blood glucose, HbA1c, and hypoglycaemic episodes, compared with multiple daily injections.2 3 4 5 6 7 8 A recent meta-analysis, however, showed that the benefits might not be as great as was previously hoped, particularly in younger children.9 In the UK, guidelines from the National Institute for Health and Clinical Excellence recommend continuous subcutaneous infusion when multiple dose therapy has failed in patients with HbA1c concentrations greater than 7.5%.10
A disadvantage of using a pump is that ketoacidosis can occur quickly if a problem with insulin delivery occurs, because no background of long acting insulin is available. We describe a case of diabetic ketoacidosis caused by insulin degrading in the reservoir of a pump in sunlight and heat.
Case report
An 11 year old girl with type 1 diabetes presented to the emergency department with vomiting and abdominal pains. She had a blood glucose concentration of 20.6 mmol/l, ketonuria (+++), and acidosis (pH 7.14). She had had diabetes since age 7 years and had been using an insulin pump for 11 months. Control of her condition had been reasonable …
Sign in
Personal subscribers, sign in here:
Article access
Article access for 1 day
Purchase this article for £20 $30 €32*
The PDF version can be downloaded as your personal record
CiteULike
Connotea
Del.icio.us
Digg
Facebook
Reddit
Technorati
Twitter
Stumbleupon
Rapid responses
Latest Responses
Evidence Based Medicine-Boondoggle?
Published 8 February 2012
Wills and wishes in organ donation
Published 8 February 2012
Re: Lessons from America
Published 8 February 2012
Boosting the role of low-molecular-weight heparins in primary PCI
Published 8 February 2012
Re: Should UK membership exams be held overseas? Yes
Published 8 February 2012
Most responses
Does anyone understand the government’s plan for the NHS? (17 responses)
Published 17 Jan 2012
Bad medicine: medical nutrition (15 responses)
Published 18 Jan 2012
Wakefield sues BMJ over MMR articles (5 responses)
Published 10 Jan 2012
Search for evidence goes on (5 responses)
Published 17 Jan 2012
How much of a social media profile can doctors have? (5 responses)
Published 23 Jan 2012