We report three cases of hypoglycaemia in non-diabetic non-obese Japanese inpatients who had schizophrenia and were being treated with a second generation antipsychotic. The clinical findings of hypoglycaemia emerged typically 2-3 hours after meals in all patients during escalation of the dose of second generation antipsychotic. No other antipsychotic or concomitant drug with a metabolic effect was coadministered.

Case 1—A 27 year old woman who took 400 mg of quetiapine a day complained of dizziness, tremor, and palpitations on day 112 of her inpatient stay. These symptoms worsened with a 600 mg daily dose of quetiapine (day 132). At this point, her blood glucose three hours after lunch was 3.2 mmol/l. Her symptoms …