Letters POPADAD trial

Don’t stop taking aspirin

BMJ 2008; 337 doi: http://dx.doi.org/10.1136/bmj.a2581 (Published 19 November 2008) Cite this as: BMJ 2008;337:a2581
  1. Peter Elwood, honorary professor1
  1. 1School of Medicine, Cardiff University, Cardiff CF14 4XN
  1. elwood{at}doctors.org.uk

    The POPADAD trial shows no benefit from daily prophylactic aspirin (hazard ratio 0.98; P=0.87) in people who have diabetes and early peripheral arterial disease. However, no firm conclusions should be drawn from a single trial, but the result be incorporated in a meta-analysis of all available evidence from relevant trials.1

    The absence of evidence of benefit is not surprising as the trial was seriously underpowered. The annual …

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