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Acute psychosis caused by co-amoxiclav

BMJ 2008; 337 doi: http://dx.doi.org/10.1136/bmj.a2117 (Published 22 October 2008) Cite this as: BMJ 2008;337:a2117
  1. Claire L Bell, specialist trainee1,
  2. Bruce Watson, senior clinical pharmacist2,
  3. W Stephen Waring, consultant physician1
  1. 1Scottish Poisons Information Bureau, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA
  2. 2Pharmacy Department, Royal Infirmary of Edinburgh, Edinburgh EH16 4SA
  1. Correspondence to: W S Waring s.waring{at}ed.ac.uk

    Co-amoxiclav is a fixed dose combination of amoxicillin and clavulanate that offers antibacterial activity against some strains that produce β lactamase. Recognised adverse effects include exfoliative dermatitis, deranged liver biochemistry, and anaphylaxis.1 We report the occurrence of acute psychosis after giving co-amoxiclav, with a strong temporal relationship and recurrence after drug rechallenge.

    Case report

    A 55 year old woman was prescribed oral co-amoxiclav for suspected pneumonia. Within two hours …

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