- Alexandre Rozenholc, resident, gynaecology and obstetrics,
- Patrick Petignat, consultant gynaecological oncologist
- 1Gynaecology and Obstetrics Department, Geneva University Hospitals, 1211 Geneva 14, Switzerland
- Correspondence to: P Petignat patrick.petignat{at}hcuge.ch
A 24 year old woman, gravida 1 para 1, presented with a request for contraception four months after delivery of a healthy baby and a normal placenta. She did not breastfeed, was asymptomatic, and did not have a return of menses (postpartum amenorrhea). A urinary pregnancy test was performed, which was positive. Transvaginal ultrasonography showed no intrauterine or extrauterine pregnancy; the endometrium was regular, 3 mm thick; and the ovaries were normal. The concentration of serum human chorionic gonadotrophin (hCG) was 92 713 IU/l (normal <5 IU/l), and one week later it was 117 056 IU/l. She underwent dilatation and curettage, and the pathological specimen showed no decidua or trophoblastic tissue. Hysteroscopy and laparoscopy showed a normal uterine cavity, tubes, and ovaries. A thoraco-abdominal computed tomography scan and magnetic resonance imaging of the brain showed no abnormality.
Questions
1. What is your diagnosis?
2. What are the prognostic factors?
3. Which treatment do you recommend?
Answers
Short answers
1. The diagnosis is a gestational trophoblastic neoplasia, most likely a choriocarcinoma.
2. Prognostic factors include age; type of pregnancy; time interval from the pregnancy; pre-treatment hCG concentration; tumour size, sites, and number of metastases; and previous chemotherapy.
3. High risk patients (those with a FIGO (International Federation of …
Sign in
Article access
Article access for 1 day
Purchase this article for £20 $30 €32*
The PDF version can be downloaded as your personal record








CiteULike
Connotea
Del.icio.us
Digg
Facebook
Mendeley
Reddit
Technorati
Twitter
Stumbleupon
Rapid responses
Latest Responses
Re: Ventilator associated pneumonia
Published 30 May 2012
Re: Restless legs syndrome
Published 30 May 2012
Author's reply
Published 30 May 2012
Re: Full access to trial data holds many benefits and a few pitfalls, conference hears
Published 30 May 2012
Restless Legs Syndrome: Fact or Fiction
Published 30 May 2012
Most responses
Venous thrombosis in users of non-oral hormonal contraception: follow-up study, Denmark 2001-10 (12 responses)
Published 10 May 2012 - 23:32
The psychiatric oligarchs who medicalise normality (9 responses)
Published 2 May 2012 - 15:42
Are doctors justified in taking industrial action in defence of their pensions? No (8 responses)
Published 8 May 2012 - 12:21
Are doctors justified in taking industrial action in defence of their pensions? Yes (8 responses)
Published 8 May 2012 - 12:21
The hardest thing: admitting error (7 responses)
Published 2 May 2012 - 12:27