Letters Hormone replacement therapy

HRT in premature menopause

BMJ 2008; 337 doi: https://doi.org/10.1136/bmj.a1668 (Published 16 September 2008) Cite this as: BMJ 2008;337:a1668
  1. Margaret C P Rees, reader in reproductive medicine, University of Oxford1
  1. 1Women’s Centre, John Radcliffe Hospital, Oxford OX3 9DU
  1. margaret.rees{at}obs-gyn.ox.ac.uk

    Grant’s blanket statement,1 based on the WISDOM study,2 that “it would be irresponsible to think that any use of hormone replacement therapy (HRT) is justifiable” will confuse those dealing with women with early ovarian failure in their 20s and 30s. National guidelines recommend the use of HRT in this group until the average age of the natural menopause in the early 50s.3 The results of the WISDOM study, which randomised women with a mean age of 63.8 years, should not be extrapolated to them.


    Cite this as: BMJ 2008;337:a1668


    • Competing interests: None declared.


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