Long term use of proton pump inhibitors raises risk of osteoporosis

BMJ 2008; 337 doi: (Published 13 August 2008) Cite this as: BMJ 2008;337:a1272
  1. David Spurgeon
  1. 1Quebec

    Patients who use proton pump inhibitors for seven or more years to treat reflux, peptic ulcers, and other conditions are at more risk of fractures related to osteoporosis, a large Canadian study has found (CMAJ 2008;179:319-26, doi: 10.1503/cmaj.071330).

    Short term exposure did not seem to raise risk of fractures, but risk of hip fracture was more after five years of continuous exposure and risk of any fracture was more after seven years of continuous exposure.

    The authors of a related commentary note that three other large studies of administrative databases have found that proton pump inhibitors increase …

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