BMJ 2008; 336 doi: https://doi.org/10.1136/bmj.39576.648472.47 (Published 15 May 2008) Cite this as: BMJ 2008;336:1138

A retrospective review of 100 confirmed cases of malignant melanoma shows that biopsies were inappropriate in a significant proportion. It also found that national guidelines for suspected melanoma—which recommend a prompt, full thickness excision biopsy allowing both a diagnosis and an assessment of the Breslow thickness of the lesion—are not being followed. Not only were punch biopsies being performed even when excision biopsy is feasible, but only a small proportion of patients were seen within 14 days of referral (Annals of the Royal College of Surgeons of England 2008;90:322-5; doi: 10.1308/003588408x285856).

Persistent enhanced attention and spatial memory in young animals have been linked to supplementation with choline during fetal development, and deficits show up when choline is restricted. But in human children aged 5 years, IQ and visuospatial processing were not related to maternal and cord blood choline concentrations (American Journal of Clinical Nutrition 2008;87:896-902; www.ajcn.org).

Acute respiratory distress syndrome (ARDS) can complicate mechanical …

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