MinervaBMJ 2008; 336 doi: https://doi.org/10.1136/bmj.39513.570313.80 (Published 13 March 2008) Cite this as: BMJ 2008;336:622
Why do patients with progressive supranuclear palsy fall? The answer may be found in their inner ears. It has long been suspected that abnormal vestibulospinal reflexes are partly to blame, but neurologists now think it is more likely to be related to abnormal otolith responses (Neurology 2008;70:802-9 doi: 10.1212/01.wnl.0000304134.33380.1e). The evidence comes from testing the otolith-ocular reflexes in nine patients with this condition. They all had responses that were around 12% of those seen in controls.
While the debate about the National Institute for Health and Clinical Excellence’s advice that all patients undergoing elective hip replacement be given low molecular weight heparin carries on, orthopaedic surgeons in Bristol say their study of mortality after elective total hip replacement strongly suggests that patients should be given aspirin after the operation. At 90 days, with routine administration of aspirin, cardiovascular deaths dropped from 0.75% to zero (Journal of Bone and Joint Surgery [Br] 2008;90-B:306-7 doi: 10.1302/0301-620X.90B3).
A meta-analysis of 21 studies involving children aged 3-18 years found substantial evidence …
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