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Hormone replacement therapy quadruples risk of breast cancers

BMJ 2008; 336 doi: https://doi.org/10.1136/bmj.39461.443877.4E (Published 17 January 2008) Cite this as: BMJ 2008;336:116
  1. Susan Mayor
  1. 1London

    Postmenopausal women taking combined oestrogen and progestin hormone replacement therapy for three years or longer run four times the risk of developing lobular breast cancer, finds US research. This is shorter than the time associated with an increased risk of other types of breast cancer (Cancer Epidemiology, Biomarkers & Prevention 2008;17:43-50).

    The study included 1044 women between the ages of 55 and 74 who had been diagnosed as having invasive breast cancer between 2000 and 2004 and entered into the cancer surveillance system in Washington state. They were compared with 469 age matched …

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