Letters Overprescribing PPIs

Time for a hospital antacid policy on Clostridium difficile

BMJ 2008; 336 doi: https://doi.org/10.1136/bmj.39458.465845.3A (Published 17 January 2008) Cite this as: BMJ 2008;336:109
  1. Jecko Thachil, SpR
  1. 1Liverpool University, Liverpool
  1. jeckothachil{at}yahoo.co.uk

    Forgacs and Loganayagam mention the increasing risk of Clostridium difficile infection with use of proton pump inhibitors (PPIs) in hospitals.1 The ability of the vegetative form of C difficile to survive in gastric contents with a raised pH caused by excess use of PPI has been proposed as a potential mechanism. …

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