BMJ 2007; 335 doi: https://doi.org/10.1136/bmj.39422.530000.47 (Published 13 December 2007) Cite this as: BMJ 2007;335:1270

Aside from all the studies that show that p53 gene is the “guardian of the genome” in tumour prevention, little else is known about its normal function. Nature (2007;450:721-4; doi: 10.1038/nature05993) reveals that p53 regulates reproduction in female mice through the gene that encodes leukaemia inhibitory factor, which is critical for implantation. Evidence is building up that p53 may have a similar function in humans.

Researchers used existing national guidelines for the provision of care for adults with epilepsy, together with systematic reviews on the topic and ideas from patient focus groups, to develop a comprehensive list of indicators of quality of care. Each indicator was appraised for its appropriateness, reliability, and necessity by an expert panel. Of the total of 37 evidence based and 10 patient based indicators, just 24 evidence based and five patient based indicators made the grade, and nine were tossed out as being unnecessary for high quality care (Neurology 2007;69:2020-7; doi: 10.1212/01.WNL.0000291947.29643.9f).

Children in front facing …

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