Re: Child-parent screening for familial hypercholesterolaemia: screening strategy based on a meta-analysis
There is a link between diffuse endothelial dysfunction , a predictor of atherosclerosis closely to vasculitis .There is a mechanism of endothelial damage and low density lipoprotein oxidation, promoted by the inflammatory microenvironment .Anti-endothelial cell antibodies found in vasculitis , systemic lupus erythematosus and the antiphospholipid syndrome have also been shown both to activate and precipitate endothelial dysfunction .Antinuclear antibody positivity is associated with decreased carotid elasticity in women .Several invasive and non-invasive techniques may be useful in endothelial dysfunction and arterial stiffness .Monitoring IMT( intima – medial thickness) is an excellent evaluation of risk stratification.
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Competing interests: No competing interests