The two types of intrauterine contraceptive device have very different menstrual side effects. The newer hormonal levonorgestrel intrauterine system (LNG-IUS or Mirena) reduces menstrual flow, whereas the copper bearing devices may induce longer, heavier, and more painful periods. Pain and heavy menstrual bleeding are common reasons for discontinuing use of an intrauterine device within the first year. Non-steroidal anti-inflammatory drugs (NSAIDs) can reduce cramping and blood flow in women with and without devices.

A recent Cochrane review by Grimes and colleagues evaluated data from 15 randomised controlled trials investigating the effect of NSAIDs on treatment or prevention of pain and bleeding due to an intrauterine contraceptive device.1 Trials meeting selection criteria were conducted in 10 countries using a range of treatments (NSAID compared with placebo, another NSAID, or another type of drug) and a variety of quantitative and qualitative outcome measures—factors that precluded a meta-analysis of the data. Although …