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Lowering homocysteine doesn't reduce the risk of thromboembolism

BMJ 2007; 334 doi: https://doi.org/10.1136/bmj.334.7606.1244-b (Published 14 June 2007) Cite this as: BMJ 2007;334:1244

Observational studies have found an association between raised total homocysteine concentrations in the serum and venous thromboembolism. Homocysteine is thought to promote thrombosis by enhancing platelet aggregation, increasing thrombin generation, impairing fibrinolysis, and causing endothelial dysfunction.

A placebo controlled trial carried out in 145 centres in 13 countries enrolled more than 5500 people who were over …

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