The evidence on gene mutations in hereditary diffuse gastric cancer is accumulatingBMJ 2007; 334 doi: http://dx.doi.org/10.1136/bmj.334.7606.1244-a (Published 14 June 2007) Cite this as: BMJ 2007;334:1244
Hereditary diffuse gastric cancer is an autosomal dominant syndrome of cancer susceptibility. It is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterised by a high risk for early onset diffuse gastric cancer or lobular breast cancer. The ability to detect CDH1 mutations and thereby identify the syndrome might …
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