Look at all the evidence before stockpiling amantadineBMJ 2007; 334 doi: https://doi.org/10.1136/bmj.39136.489942.FA (Published 01 March 2007) Cite this as: BMJ 2007;334:439
- Tom Jefferson, Cochrane Acute Respiratory Infections Group
- Anguillara Sabazia, Rome 00061, Italy
Tsiodras et al propose testing amantadine to see if any benefits could accrue in combination with neuraminidase inhibitors in pandemic flu.1 The principal attraction seems to be low cost. Although they quote resistance and harms as well as lack of “any demonstrable reduction in transmissibility or pathogenicity,” this does not seem to deter them from their proposal.
Had they consulted the Cochrane Library, they …