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Antibiotics in second trimester may reduce risk of preterm birth

BMJ 2007; 334 doi: https://doi.org/10.1136/bmj.39111.364410.DB (Published 01 February 2007) Cite this as: BMJ 2007;334:224
  1. Barbara Kermode-Scott
  1. 1Alberta

    Giving macrolides or clindamycin during the second trimester of pregnancy to women at risk of preterm births can lower the risk, a new systematic review and meta-analysis by Canadian researchers indicates. But the study also found that giving metronidazole alone in the second trimester is linked with a greater risk of preterm birth in the high risk population.

    The study's authors, from the University of Montreal and Laval University, Quebec, say that delivery before 37 weeks' gestation complicates between 7% and 11% of all pregnancies, is the leading cause of perinatal morbidity and mortality, and is …

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