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Worldwide increasing demand for traditional remedies along with clinical trials on herbal medicines and scientific recommendations to develop systematized and integrated traditional medicine make a turning point now (1). This means that balance between these factors can help us to solve our healthcare challenges such as Diabetes Mellitus, Hypertension and Hyperlipidemia.
Reference selection is one of the most important steps for performing a clinical trial. Among Iranian Traditional Medicine texts, we can name The Kitab al-Hawi known as Liber Continens. This book that was written by Rhazes is one of the most ancient, detailed and famous books among these texts.
Abubakr Muhammad Ibn Zakaria Razi is known to the western world as Rhazes (b: 865 AD, Ray near Tehran — d: Ray, 925 AD) and was one of the most creative and famous Medieval Iranian scientists. He wrote more than 200 books in a variety of fields such as Medicine, Music and Chemistry (2, 3, 4).
Rhazes in this 26 volumes book, allocated the 20 & 21th volumes to natural remedies, mainly herbal. He explained, alphabetically, each herb with its different names, used part of plant, various dosage forms for different diseases and its possible adverse reactions with their management (5).
In addition, he explained previous scholars' comments about each herb. For example, he cited Dioscorides and Galen several times. However he sometimes criticized their theories according to his own observations and clinical practices.
It seems that reviewing of traditional medicine texts of ancient civilizations can help us to make novel subjects for clinical trials.
1. World Health Organization. WHO Traditional Medicine Strategy 2002-2005.
2. Gorji A., Khaleghi Ghadiri M. History of epilepsy in Medieval Iranian medicine. Neurosci Biobehav Rev.2001 Jul; 25(5):455-61.
3. Tabei SZ., Riazi A., Medical Sciences in the Third Millennium: An Avicennian Approach. Iran Red Crescent Med J. 2009; 11(1):4-9.
4. Zarshenas MM., Mehdizadeh A., Zargaran A., Mohagheghzadeh A. Rhazes (865–925 AD). J Neurol. 2012 May; 259(5):1001-2.
5. Abu Bakr Mohammad ibn Zakariya Razi. Al-Hawi. Tehran: Ministry of Health and Medical Education of Iran, Committee of Computerizing Medicine and Hygiene, 2009.
Competing interests: None declared
Research center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
I am just wondering if you have read 'The Decade of Medicine or The Physician of the Rich and the Poor' 'in which all the signs Causes and Remedies of Diseases are Clearly 'Expounded', by Francois Du Port? It was written initially in Latin text in 1694 and published with the 'Permission and Approval of the (French) King'. It gives a fascinating insight into medical science in the 17th century. After 286 years the book was found by chance by a German man on holiday and subsequently translated into English in 1980. If anybody wants a copy of this translated copy (free) please email me on soostevens@hotmail.com as it seems it is still a rarity.
Competing interests: None declared
none, cf14
Ginger is mostly popular in medical literature for its therapeutic effect in nausea and vomiting specially in pregnancy. However it is also popular in traditional medical approaches for wide variety of conditions such as neurologic diseases.
Multiple recent researches tried to evaluate therapeutic effects of ginger in neurologic diseases (1). It seems to be interesting that more than ten centuries ago ancient Persian scholars have also commented on this topic. Avicenna has described neurologic medicinal uses of ginger in his medical encyclopedia, “Avicenna canon of medicine”.
Avicenna is one of the most famous ancient scholars, who wrote almost 450 treatises on a wide range of subjects, of which around 240 have survived. In particular, 40 of his surviving treatises concentrate on medicine (2) that “canon of medicine” is the most popular one. He discusses many diseases such as headache, stroke, epilepsy, coma and bell’s palsy in a chapter on neurology (3).
He has written interesting points about ginger in the treatment of neurologic diseases. He also suggested ginger as treatment of geriatric memory deficits. He has also mentioned ginger in the treatment of epilepsy: “Patients with epilepsy can take ginger powder nasally.”
Also in the treatment strategy of stroke he says: “After this step patient should gargle with ginger.” He believed that this can open obstructions in brain vessels. He has also used ginger in the treatment of bell’s palsy: “Patient should take ginger with honey every morning.”
Review of historical uses of medicinal herbs can helps us in the creation of new hypotheses.
References
1- White B., Ginger: an overview. Am Fam Physician. 2007 Jun 1;75(11):1689-91.
2- Gorji A., Khaleghi Ghadiri M. History of epilepsy in Medieval Iranian medicine. Neurosci Biobehav Rev. 2001
Jul;25(5):455-61.
3- Avicenna, The Canon of medicine (Persian translation), 3rd edition. Tehran: Ministry of Health and Medical Education of Iran, Committee of Computerizing Medicine and Hygiene, 2007.
Competing interests: None declared
Research center for traditional medicine and history of medicine, Shiraz University of Medical Sciences, Shiraz, Iran
9 January 2008
In respose to the given article we would like to report our findings. There are numerous medicinal plant extracts which have been used as remedies against several human ailments . However , not all of them have been established as neutraceuticals .One such plant is Garcinia sp. It is a much neglected plant . Though it has been known for its culinary properties , the fruit extract from this plant is not very widely used as an antimicrobial agent. The fruit is known to posses good amounts of tartaric and malic acids. The plant commonly known as Kokum , is found to grow in western coasts of India.
We report our work on one of its species Garcinia indica. Fruit extract
obtained from this plant was seen to have antimicrobial activity against
following bacterial strains:
1.Bacillus subtilis
2.Echerichia coli
3.Mycobacterium phlei
4.Proteus vulgaris
5.Pseudomonas aerugenosa
6.Staphylococcus aureus
The procedure involved pour plate technique ,wherein above mentioned bacterial cultures(following 24 hours of incubation), were diluted directly in tubes of liquid cooled agar medium in a ratio of 1:10. The medium was maintained at a temperature of 45 degrees Celcius to allow thorough distribution of the inoculum. The inoculated medium was dispensed into Petri plates and allowed to solidify. Then extract was added to a well , punched asceptically in the centre of the plate. The results were observed after 48 hours.
There were well marked clear zones , which proved anti microbial effects of the extracts. The above stated results are restricted to invitro conditions only and we do not claim to have seen any in vivo effect so far. We suggest that Kokum fruit extract can be used as a potent antimicrobial agent in external hygiene purposes. This may include hand washes and oral washes.
We also suggest that use of this extract can improve conditions of oral and esophageal ulcers, which also involve bacteria. However, this has not been experimentally proved and the suggestion is purely hypothetical.
Competing interests: None declared
Competing interests: None declared
NATIONAL INSTITUTE OF VIROLOGY
7 February 2007
Dear Editor I enjoyed reading the article by Buenz EJ et al drawing attention to the life of G E Rumphius on his text, Ambonese Herbal. Many years ago in writing an historical paper on Rauwolfia and Ancient Medical Writings of India² I came across a reference by Woodson³ which illustrated an engraving of Rauwolfia from Rumphius' supplement to the Herbarium Ambionse published in 1755. Rumphius (Rumpf) was sometimes known as the 'Pliny of India" and had been sent by the Dutch East India Company to the island of Amboina to collect data on useful and remarkable plants on the spice islands. In the text by Woodson³ on Rauwolfia it is stated that the manuscript of Rumpf was published long after his death by Burmann in Amsterdam.
Specifically, in the case of Rauwolfia, one of the alkaloids, reserpine, became a widely used anti-hypertensive agent in the 1950s. Rauwolfia was known in Indian Materia Medica for many years and is cited in the Susruta Samhita by the name Sarpagandha. The Sanskrit name is derived from two words, sarpa m. snake, the Sanskrit word resembling the latin serpens, and gandha m.smell. It was Vaikil who first drew attention in the western world to the antihypertensive effects of Rauwolfia, used in its crude form, in an article in the British Heart Journal in 1949.
References
1. Buenz, E.J., Bauer, B.A., Johnson, H.E., Tavana, G etal
Searching historical herbal texts for potential new drugs, BMJ, 2006; 333:1314-5 Somers, K. Notes on Rauwolfia and Ancient Medical Writings of India. Medical History II 1958; 87-91(1958); 3. Woodson, R.E.
In Rauwolfia, Botany, Pharmacognosy, Chemistry and Pharmacology, 1957 Little Brown & Co, Boston Vaikil, R.J. Brit Heart Journal XI 1949; 350 et seq
Professor Krishna Somers MB BCh (Rand) FRCP (Lond & Edin) FRACP FACC DCH Level 3, Ainslie House 48 Murray Street Perth 6000 Western Australia Ph: +61 (0) 8 92242589 Fax: +61 (0) 8 9221 3323 Email: krishna.somers@health.wa.gov.au
Competing interests: None declared
Competing interests: None declared
Royal Perth Hospital
17 January 2007
Pierre Cabalio,
I applaud your astute observation regarding the image in the article. In the original manuscript submitted to BMJ Figure 1 illustrated the similarities between the Atuna racemosa voucher specimens collected in Independent Samoa and the original plates from Rumphius. The similarities are striking. In an editorial decision, the comparison figure was replaced with an alternate color figure. Fortunately, the original plate is available on the New York Times website (http://www.nytimes.com/2007/01/16/health/16herb.html?ex=157680000&en=aef...)
Additionally, when we originally performed the data mining of the historic herbal text,1 we strictly employed peer-reviewed literature using the NAPRALERT database. Thus, the references you provided were not included in the original search. It was a weighted decision to establish this cutoff point, however limiting the comparison to peer-reviewed literature allowed a defined and reproducible (even if perpetually expanding) dataset.
It is my hope that this work demonstrates the importance of traditional medicine knowledge and the potential great costs incurred through the loss of this knowledge. To have information that took thousands of years of trial-and-error experimentation disappear in a couple centuries is a loss the world can do without.
Eric J Buenz
1. Buenz EJ, Johnson HE, Beekman EM, Motley TJ, Bauer BA. Bioprospecting Rumphius's Ambonese Herbal: Volume I. J Ethnopharmacol 2005;96(1-2):57-70.
Competing interests: None declared
Competing interests: None declared
BioSciential, LLC, Rochester, MN, 55903, USA
3 January 2007
Dear author,
Atuna racemosa is also used in remedies against diarrhoea in Solomon islands (Clarke & Thaman 1993) and against infections in Fiji (Cambie & Ash 1994) which justifies research of antibacterial activities, but not only. If Rumphius said that the Atuna racemosa remedy was recommended on " all kinds of diarrhea ", it might be interesting to test it on protozoa like amibs, a classic cause of dysentery, not only Gram+ and Gram - bacteria.
It may be noted that the illustration for Atuna racemosa was probably different in Rumphius's text. The one shown curiously looks like a coconut tree. Atuna racemosa susbsp. excelsa can be seen in Flora Malesiana, Fig 19, p. 668, Ser. I, vol 10
Sincerely Yours,
Pierre Cabalion,
IRD Noumea
Cambie RC, Ash J, 1994. Fijian medicinal plants. 365p, CSIRO, Australia.
Clarke WC, Thaman RR (Eds.), 1993. Agroforestry in the Pacific Islands: Systems for Sustainability. 307 p., The United Nations University,Tokyo, New York, Paris.
Competing interests: None declared
Competing interests: None declared
IRD, Noumea, BP A5, 98848 NOUMEA, N.Caledonia
26 December 2006
Western trained practitioners in the Third World, especially Africa, should be very grateful to Dr Buenz and colleagues [1] for having “recovered lost knowledge of traditional medicine” (Dec 23 2006, p 1314). Our training tends to make us equate all traditional medical practitioners with “witch doctors”, and so we are reluctant to investigate therapeutic successes that take place without our intervention.
The “historical texts on herbal medicine” [1] have all been compiled from oral tradition, hence in my plea for the urgent need to probe “anecdotes in traditional African therapeutics” [2] I once described how the WHO Global AIDS Office in Geneva had told me on Monday 2 February 1987 about an African country where a British Surgeon “had discharged a young man to die from AIDS but who came back to show himself to the surgeon about a year later, apparently well”. During my tour for investigating AIDS at the grass roots in African countries, I traced that British surgeon, and he confirmed what the WHO had told me. [2]
The greatest “historical text on herbal medicine” [1] and by far the most detailed that had been produced from Africa was by Dr John Watt and Dr Maria Breyer-Brandwijk [3] who not only compiled meticulously some tribal names of the plants and their uses, but also indicated with pictures what the plants were, their botanical names, and the diseases they were used for by the natives of which countries and tribes. Talking about “mining” [1], this 1457-page book of Watt and Breyer-Brandwijk is a veritable gold mine of therapeutic information. But do we Africans go digging as Buenz and colleagues have done? No! Even when Kenya Medical Research Institute [KEMRI] has demonstrated the remarkable effect of the Neem, Azadirachta indica, against the malaria parasite [4], and the benefits of Artemisia Annua have been demonstrated, African Ministries of Health prefer to continue importing Mefloquine with its 50 side effects clearly documented in the British National Formulary [5].
Perhaps when we come to realize that the great Mayo Clinic does not despise traditional herbal therapeutics, sub-Saharan African universities will begin to advise their Ministries of Health to stop importing harmful drugs. The British experts, Fenwick and Hanley, who catalogued the beneficial therapeutic benefits of the Allium family of vegetables, benefits of which included serum cholesterol lowering and antibiotic effects, came near to a vital truth when they hinted that some of the drug firms already have herbal answers to many problems but “lack of patent protection is but one of the factors militating against the examination and exploitation of the beneficial effects” of many natural products [6]. The Mayo Clinic has gone ahead to put in place their patenting procedures without relying on drug companies [1]. Why don’t African Health institutions learn from the Mayo Clinic?
“Unless Africans can find alternative sources of therapeutic measures in traditional medicine” I once lamented, “the future is bleak indeed, because even with improvement in public health measures, people will still require drug treatment. We therefore need to collect and record all anecdotes, including the embarrassing and most primitive ones. By sifting through them carefully we can use our scientific knowledge not only to discard harmful practices, but also discover hidden treasures”. [2]
Competing interests: None declared.
1 Buenz EJ, Bauer BA, Johnson HE, Tavan G, Beckman EM, Frank KL, Howe CL. Searching historical texts for potential new drugs. BMJ 2006; 333:1314-5.
2 Konotey-Ahulu FID. Probing anecdotes in traditional African therapeutics. African Journal of Health Sciences. 1994; 1:53-56.
3 Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. (Being an Account of their Medicinal and Other Uses, Chemical Composition, Pharmacological Effects, and Toxicology in Man and Animal) – 2nd Edition. Edinburgh and London: E & S Livingstone Ltd. 1962(1457 pages).
4 Kofi-Tsekpo WM, Rukunga GM, Aluoch JA, Kahn B, Waiyaki PG, Tolo F, Muthotho N. A preliminary investigation of a traditional medicine (KRM 913) as a potential antimalarial and antiparasitic agent. In Kinot SN, Omuse JK and Kofi-Tsekpo WM (Eds) Proceedings of The Annual Medical Scientific Conference, Nairobi, Kenya 1989.
5 Konotey-Ahulu FID. Doctors must not be lapdogs to drug firms: even more relevant to the Third World. BMJ Rapid response http://www.bmj.com/cgi/eletters/333/7576/1027 Nov 12 2006
6 Fenwick G. Hanley AB. The genus Allium – Part 3 Section X Medicinal Effects. CRC Critical Reviews in Food Science and Nutrition 1985; 23: 1-73.
Competing interests: None declared
Competing interests: None declared
Consultant Physician & Haemoglobinopathy Counsellor, Ten Harley Street, London W1N 1AA, England









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