Possible cause of false normal B-12 assays

BMJ 2006; 333 doi: http://dx.doi.org/10.1136/bmj.333.7569.654-c (Published 21 September 2006)
Cite this as: BMJ 2006;333:654.4

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  1. Malcolm S Hamilton, director (m.s.hamilton@talk21.com),
  2. Sheena Blackmore, deputy director,
  3. Anne Lee, scheme scientist
  1. United Kingdom External Quality Assessment Scheme, UKNEQAS Haematinics, Department of Haematology, Good Hope NHS Trust, Sutton Coldfield B77 7RR
  2. United Kingdom External Quality Assessment Scheme, UKNEQAS Haematinics, Department of Haematology, Good Hope NHS Trust, Sutton Coldfield B77 7RR

    EDITOR—In response to Devalia,1 we report a further eight cases of serum samples from patients with megaloblastic anaemia or subacute combined degeneration of the cord in whom current assays have failed to detect cobalamin deficiency. The cobalamin results were well within the manufacturers' reference range and not to do with cut-off point. The table shows results from two cases of megaloblastic anaemia, which subsequently responded …

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