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Statins work better at higher doses in patients with coronary heart disease

BMJ 2006; 333 doi: https://doi.org/10.1136/bmj.333.7567.0-e (Published 07 September 2006) Cite this as: BMJ 2006;333:0-e

Research question Standard doses of statins save lives and prevent cardiovascular events in patients with coronary heart disease. Do high doses work any better?

Answer Yes. High doses prevent more cardiovascular events, including heart attacks and strokes

Why did the authors do the study? The clinical benefits of standard doses of statins are well established, but doubt remains over the potential benefits of increasing the dose. Several large trials have been done comparing the two approaches, but results have been mixed.

What did they do? These authors searched systematically for all randomised trials comparing standard dose with high dose statins in patients with coronary heart disease. They included only those trials …

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