MinervaBMJ 2006; 333 doi: https://doi.org/10.1136/bmj.333.7558.104 (Published 06 July 2006) Cite this as: BMJ 2006;333:104
What induces malignant melanomas in people without sun damage? US scientists report that fair skinned people who inherit variants of MC1R, which encodes a pigment receptor, have a higher risk of developing melanomas with mutations in the BRAF gene, an oncogene associated with melanomas that occur with little chronic damage to the skin. They think there's a link between the two genetic variants, but the mechanism is still unknown (www.sciencexpress.org/29June2006/Page1/10.1126/science. 1127515).
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