Commercial influence and the content of medical journalsBMJ 2006; 332 doi: http://dx.doi.org/10.1136/bmj.332.7555.1444 (Published 15 June 2006) Cite this as: BMJ 2006;332:1444
- 1 School of Health Policy and Management, York University, Toronto, ON, Canada
- 2 University of Medicine and Dentistry of New Jersey, Stratford, NJ, USA
- Correspondence to: J Lexchin, 121 Walmer Road, Toronto, ON, Canada M5R 2X8
- Accepted 28 April 2006
How confident should we be in the objectivity of medical journals? Do commercial biases play a part in determining what appears in print?
Authors of articles in medical journals may be affected by commercial bias. Whether this same concern applies to the editors and owners of journals has rarely been critically examined.1 2 Our article explores the reasons for concern. We use information in the literature on three important questions. Do financial conflicts of interest affect decisions made by journal editors? Do journals have policies on authors' conflicts of interest, and how well do editors enforce those policies? Do financial considerations affect the content of medical journals? We end with a proposal for future research that would help to advance this debate.
Sources of bias
Government organisations and societies of health professionals can also influence journal content. A former editor of JAMA was fired by the American Medical Association because of political sensitivity over an article on oral sex that he published at the time of President Clinton's impeachment.3 An article in CMAJ on the information requested by pharmacists before dispensing postcoital contraception was changed after complaints by the Canadian Pharmacists Association about whether the research was ethical.4 However, we think that the greatest potential for bias comes from commercial influences, hence the direction of our article.
Conflicts of interest
Because journal editors have a great deal of control over original scientific articles, commentaries, and editorials, any commercial bias due to their own conflict of interest would affect the content of their journals.5 Only one systematic study has examined editors' policies on conflict of interest (financial and non-financial). Nine of 30 peer reviewed general and internal medical journals, including the top four by impact factor (a measure of frequency of citation), had an explicit policy for dealing with editors' financial conflicts of interest. Only eight of the remaining journals intended to declare such conflicts in the next couple of years. Reasons for non-disclosure were that disclosure is unnecessary, that editors do not have conflicts, and that the question had never been raised.6 7
An article about the benefits of escitalopram (Lexapro) over citalopram (Celexa) provides an example of apparent editorial conflict of interest. The article, by Jack M Gorman, was published in a special supplement of CNS Spectrums, a neuropsychiatric journal that he edits. The article, which was published at a time when the patent for citalopram was expiring, concluded that escitalopram significantly improved primary endpoint efficacy scores in trial subjects “much sooner” than did citalopram and was “well-tolerated.” Dr Gorman was a paid consultant to Forest (which marketed both drugs), and Forest paid Medworks Media, the publisher of CNS Spectrums, to print the article,8 although Dr Gorman stated at the time the article was published that he was not paid personally to write it.” A comparison of these two drugs published in Medical Letter, an independent drug bulletin with no advertising, found no difference between the two drugs.9
Editors might not pursue aggressive conflict of interest policies in their journals and may fail to enforce existing policies. A 1999-2000 survey of the 24 basic science journals and 24 clinical journals with the highest immediacy index rankings (how fast the average article in a particular journal will be discovered and cited) found that only 20 of the 47 that responded reported having policies for the disclosure of conflict of interest.10 Definitions of conflict of interest varied greatly, and disclosure of certain conflicts could be avoided; for instance, 10 journals required disclosure of income and equity interests, but only seven asked for patent ownership to be reported, and only one required appearances of conflicts to be reported.
Despite recent improvements in five leading medical journals in the proportion of articles declaring conflict of interest, 8% (13 of 163) original articles published from December 2003 to February 2004 in four major journals failed to declare conflicts.11 12 Narrowly defining conflicts and not vigorously enforcing journal policies may result in editorial decisions that lead to the publication of articles with a commercial bias.
Journal supplements are a good example of how financial considerations can influence the editorial content of medical journals. Supplements are mostly paid for by drug companies and usually contain articles about a single drug marketed by the company. These articles are usually based on papers presented at symposiums sponsored by drug companies. Because the publisher is paid according to the number of papers in each supplement, lax standards for these articles will generate more revenue than stricter standards.1 As a result, the scientific quality of most papers in supplements is inferior to those published in the main journal.13
Most high profile, peer reviewed journals produce press releases for newsworthy articles to generate media attention. Greater media attention leads to more subscriptions, more advertising, and the sale of article reprints, all of which result in greater revenue. Journals aggressively advertise reprint sales, as shown by an advertisement on the web page of the BMJ: “Reprints are invaluable for direct marketing, exhibitions/seminars and sales support campaigns and for mailing new product information to doctors (and for distribution) to conference delegates and visitors at exhibitions.”14 Companies may spend up to $1 million (£0.53m; €0.77m) on purchasing reprints, and the former editor of the BMJ, Richard Smith, thinks that this situation can create a conflict for journal editors: “Publish a trial that will bring US$100 000 of profit or meet the end-of-year budget by firing an editor.”1 2
Revenue from journal advertising
One study looked at the revenue from journal advertising as a proportion of the total income of six non-profit making doctors' organisations that owned journals.15 Five organisations obtained more than 10% of their gross income from advertising in their journals, and in four cases as much (or nearly as much) money was generated from advertising as from members' fees and “other assessments” (table). The authors concluded, “potential financial conflicts of interest arising from pharmaceutical advertisements in medical journals may be substantial.” Of note, journals do not routinely report details of their sources of revenue, such as subscriptions, journal advertisements, and sales of reprints.
Companies may refuse to advertise in journals that publish articles that are critical of the drugs industry. In 1992, the Annals of Internal Medicine published an article that critically examined the scientific accuracy of advertisements for drugs in 10 leading medical journals.16 Reviewers (doctors and pharmacists) judged that 34% should have been revised before publication, and 28% should not have been published. After publication of this article, the decrease in drug advertisements in the Annals was greater than in four leading general medical journals (figure).17 The journal lost an estimated $1-1.5 million in advertising revenue by publishing the study.18 The editor said, “The episode revealed the true colours of the pharmaceutical industry, which was willing to flex its considerable muscles when it felt its interests were threatened.”19 The potential effects of articles on advertising revenue may consciously or subconsciously affect editors' decisions about publication or may influence which authors are asked to contribute.
In some journals, marketing considerations seem to be more important than editorial decisions. Despite three good peer reviews, the editor of a leading nephrology journal, Transplantation and Dialysis, rejected an editorial questioning the value of epoetin in end stage renal disease. The editor admitted to the author of the editorial, “I have been over-ruled by our marketing department with regard to publishing your editorial… the publication of your editorial would, in fact, not be accepted in some quarters…and apparently went beyond what our marketing department was willing to accommodate.”20
Without drug advertising, journals are economically vulnerable. Only two general medical journals have stopped advertising drugs, and one of these had to stop publication a little more than three years after doing so.
Recommendations for action
Commercial bias in medical journals owing to financial pressure or editors' conflicts of interest would represent a fundamental threat to the credibility of journals and to science as a whole. The studies cited here provide evidence for concern about commercial influence. In this light, we recommend some easily implemented measures to help alleviate these concerns.
Journals should publish detailed information about their sources of income, including the amount they get from the sale of reprints, supplements, and advertising;
At a minimum, editors should follow the recommendations of the Committee on Publication Ethics (COPE), a forum for editors of peer reviewed journals formed to discuss issues related to the integrity of the scientific record. Editors should disclose their own relevant conflicts of interest to readers and consider disclosing those of their editorial teams, editorial boards, managers, and owners;
Journals should consider not allowing editors to have any direct financial ties (for example, stock ownership, speaker's fees, advisory board participation) to any healthcare business that advertises in the journal that they edit;
The International Committee of Medical Journal Editors (ICMJE) or a similar organisation such as the World Association of Medical Editors should design a template for journals that would record the wide range of financial interactions that authors might have with commercial entities and journals should publish these authors' statements in full, either in print or electronically, in conjunction with the articles;
Editors should consider publishing earlier versions of manuscripts on the internet together with reviewers' and editors' comments, so that readers can see how the tone and content of articles was changed. This information could help detect the origin of any bias.
All journals should be strongly encouraged to adopt these recommendations so that those that cooperate will not suffer financially compared with those that do not.
In addition, the influence of commercial interests on medical journals should be investigated systematically. A respected and independent body, such as the Institute of Medicine in the United States, should study the past five years' contents of a selection of leading medical journals and look for bias in articles that deal with specific drugs and pharmaceutical policy in general. Such a study would allow comparisons between journals and over time to detect trends in publications. The results should be reported to the profession and the public.
Most general and clinical medical journals do not have policies on conflicts of interest for their editors
Articles published in sponsored journal supplements bring in substantial revenue for the publishers of journals
Non-profit making doctors' organisations may receive more revenue from advertising in journals than from members' fees
Journals do not seem to be able to survive without advertising
Articles in medical journals that criticise the drug industry can result in substantial loss of advertising revenue
Systematic research is needed to determine whether commercial interests influence the decisions of journal editors and owners
Publishing medical journals is not a charitable venture, even when the owners are non-profit making medical societies. Considerable financial resources are needed to publish high quality journals, and owners and editors are vulnerable to economic pressures that may threaten the intellectual integrity of their journals. The medical community should objectively and dispassionately investigate whether this concern is a reality.
Contributors and sources JL has been conducting research into pharmaceutical policy for more than 20 years and has authored or coauthored more than 60 peer reviewed articles in this area, as well as serving as a consultant to various national governments and the World Health Organization on pharmaceutical matters. DL is a professor of comparative healthcare policy, a contributor to the WHO observatory volume on European pharmaceutical policy, and a member of the taskforce for the Gates Foundation on how best to make vaccines for global diseases economically viable. DL had the initial idea for the article. JL did most of the literature searching and retrieval and wrote the various drafts. DL made intellectual contributions to the analysis of the literature and helped with revisions. Neither of the authors received any financial rewards for writing this article. JL is guarantor.
Competing interests None declared.